Cloned (Comment) | Organism |
---|---|
- |
Mesocricetus auratus |
cDNA encoding beta-ARK 1 is cloned from heart and sequenced, 689 amino acids protein, 95% homology to rat and 90% homology to human beta-ARK 1 | Mesocricetus auratus |
nucleotide sequence of beta-ARK 1, 95% homology to Syrian hamster beta-ARK 1 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Rattus norvegicus | - |
ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Mesocricetus auratus | beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation | ADP + phospho-beta-adrenergic receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
Syrian hamster, healthy F1b and cardiomyopathic BIO53.58, 7, 15 and 20 weeks old, beta-ARK 1 | - |
Mesocricetus auratus | Q64682 | - |
- |
Rattus norvegicus | - |
beta-ARK 1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
heart | enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 | Mesocricetus auratus | - |
heart | significantly increased expression of beta-ARK 1 in the hearts of BIO53.58 hamsters compared to control hamsters F1b | Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | - |
Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Mesocricetus auratus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation | Mesocricetus auratus | ADP + phospho-beta-adrenergic receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-adrenergic receptor kinase 1 | - |
Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
ATP | - |
Mesocricetus auratus |