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Literature summary for 2.7.11.15 extracted from

  • Parruti, G.; Ambrosini, G.; Sallese, M.; De Blasi, A.
    Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2 (1993), Biochem. Biophys. Res. Commun., 190, 475-481.
    View publication on PubMed
Search for more literature for 2.7.11.15

Cloned(Commentary)

Cloned (Comment) Organism
cDNA encoding beta-ARK 2 is cloned, expressed in COS-7 cells and sequenced Homo sapiens
expression in COS7 cells Homo sapiens
very similar cDNA sequences of bovine and human kinases Bos taurus
very similar sequences of bovine and human kinases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
heparin
-
 Bos taurus
heparin
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid sequences of human and bovine beta-ARK 1 and 2 Bos taurus
additional information
-
 amino acid sequences of human and bovine beta-ARK 1 and 2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Bos taurus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Homo sapiens agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Homo sapiens functional role of the beta-ARK/beta-arrestin mechanism of receptor desensitization in immune cells ADP + phospho-beta-adrenergic receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2
-
Homo sapiens P35626
-
-
Homo sapiens P35626 beta-ARK 2, enzyme exists in 2 subtypes: beta-ARK1 and 2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-
cerebellum
-
 Bos taurus
-
heart moderate expression of beta-ARK 2 Homo sapiens
-
IMR-32 cell beta-ARK 2 Homo sapiens
-
leukocyte peripheral blood leukocytes Homo sapiens
-
leukocyte mononuclear, peripheral blood leukocytes, high expression Homo sapiens
-
leukocyte beta-ARK 2 Bos taurus
-
leukocyte beta-ARK 2 Homo sapiens
-
lung moderate expression of beta-ARK 2 Homo sapiens
-
additional information tissue distribution of beta-ARK 2 Bos taurus
-
additional information tissue distribution of beta-ARK 2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor functional role of the beta-ARK/beta-arrestin mechanism of receptor desensitization in immune cells Homo sapiens ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + rhodopsin in form of bovine rod outer segments Bos taurus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin in form of bovine rod outer segments Homo sapiens ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin recombinant beta-ARK 2: 40% of efficiency of beta-ARK 1 in phosphorylating rhodopsin Homo sapiens ADP + phosphorhodopsin
-
 ?

Synonyms

Synonyms Comment Organism
beta-adrenergic receptor kinase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus
ATP
-
 Homo sapiens