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Literature summary for 2.7.11.15 extracted from

  • Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
    Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity (1994), Trends Biochem. Sci., 19, 440-444.
    View publication on PubMed
Search for more literature for 2.7.11.15

Activating Compound

Activating Compound Comment Organism Structure
additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Inhibitors

Inhibitors Comment Organism Structure
additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
ATP + a protein the phosphorylase kinase phosphorylates proteins and proteolytic fragments thereof, phosphorylation of multiple residues in the substrate sequence Mammalia ADP + a phosphoprotein
-
 ?
additional information substrate specificity, the enzyme depends on basic residues for substrate recognition, the residues at the substrate phosphorylation site greatly influence the enzyme activity, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mammalia