Cloned (Comment) | Organism |
---|---|
gene GRK1, DNA and amino acid sequence determination and anaylsis of wild-type enzyme mutant genes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
P391H | a naturally occuring homozygous mutation in gene GRK1 leading to the Oguchi disease, a stationary blindness with autosomal recessive transmission, with markedly reduced cone response | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Japanese Oguchi disease patients, gene GRK1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
lipoprotein | the enzyme contains a myristoylation site at the N-terminus and a C-terminal farnesylation site, overview | Homo sapiens |
phosphoprotein | the enzyme performs autophosphorylation at Ser491 and Thr492 of the C-terminal domain | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Homo sapiens | - |
retina | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme performs autophosphorylation at Ser491 and Thr492 of the C-terminal domain | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme organization with an N-terminal region containing a myristoylation site and a rhodopsin binding site, with the central catalytic domain, and a C-terminal domain harboring an autophosphorylation site and a farnesylation site, overview | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |