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Literature summary for 2.7.11.14 extracted from

  • Rinner, O.; Makhankov, Y.V.; Biehlmaier, O.; Neuhauss, S.C.F.
    Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation (2005), Neuron, 47, 231-242.
    View publication on PubMed
Search for more literature for 2.7.11.14

Activating Compound

Activating Compound Comment Organism Structure
light
-
 Danio rerio

Cloned(Commentary)

Cloned (Comment) Organism
gene grk7a, DNA and amino acid sequence determination and analysis Danio rerio
gene grk7b, DNA and amino acid sequence determination and analysis Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information construction of grk7a-knockout fish mutants, mutant larvae are delayed in electroretinographic measurements and temporal contrast sensitivity is reduced compared to the wild-type, overview Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Danio rerio 16020
-
photoreceptor outer segment
-
 Danio rerio 1750
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cone opsin Danio rerio light-dependent phosphorylation ADP + phosphorylated cone opsin
-
 ?
additional information Danio rerio cone-specific kinase GRK7 is essential for cone vision ?
-
 ?
additional information Danio rerio for cone vision GRK1 is not essential ?
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
 i.e. Brachydanio rerio, zebrafish
-
Danio rerio Q49HM8 gene grk7b; i.e. Brachydanio rerio, zebrafish
-
Danio rerio Q49HM9 gene grk7a; i.e. Brachydanio rerio, zebrafish
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Danio rerio
-
photoreceptor
-
 Danio rerio
-
retinal cone outer segment Danio rerio
-
retinal cone outer segment GRK1-homologue GRK7a Danio rerio
-
retinal cone outer segment GRK1-homologue GRK7b Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cone opsin light-dependent phosphorylation Danio rerio ADP + phosphorylated cone opsin
-
 ?
additional information cone-specific kinase GRK7 is essential for cone vision Danio rerio ?
-
 ?
additional information for cone vision GRK1 is not essential Danio rerio ?
-
 ?

Synonyms

Synonyms Comment Organism
cone-specific kinase GRK7
-
 Danio rerio
G-protein coupled protein kinase 7a
-
 Danio rerio
G-protein coupled protein kinase 7b
-
 Danio rerio
GRK1
-
 Danio rerio

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Danio rerio