Activating Compound | Comment | Organism | Structure |
---|---|---|---|
mastoparan | enhances peptide phosphorylation | Bos taurus | |
additional information | molecular mechanisms of GRK1 activation | Bos taurus | |
rhodopsin | photolyzed rhodopsin stimulates | Bos taurus |
Application | Comment | Organism |
---|---|---|
medicine | mutation in RK is associated with the Oguchi disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Gallus gallus |
GRK1 gene encodes a 689 amino acids protein | Enteroctopus dofleini |
GRK1 gene encodes a 689 amino acids protein | Doryteuthis pealeii |
GRK1 gene with 7 exons is located on chromosome 13q34 and encodes a 561 amino acids protein | Homo sapiens |
GRK1 is cloned | Oryzias latipes |
Protein Variants | Comment | Organism |
---|---|---|
additional information | - |
Bos taurus |
additional information | RK knockout mice | Mus musculus |
additional information | GRK1 mutations causing the Oguchi disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
recoverin | Ca2+-dependent inhibition | Bos taurus | |
recoverin | Ca2+-dependent inhibition | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-bound | Bos taurus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Bos taurus | |
Mg2+ | - |
Oryzias latipes | |
Mg2+ | - |
Gallus gallus | |
Mg2+ | - |
Enteroctopus dofleini | |
Mg2+ | - |
Doryteuthis pealeii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + rhodopsin | Mus musculus | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Homo sapiens | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Rattus norvegicus | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Bos taurus | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Oryzias latipes | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Gallus gallus | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Enteroctopus dofleini | - |
ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | Doryteuthis pealeii | - |
ADP + phosphorhodopsin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Doryteuthis pealeii | Q9N2R0 | squid | - |
Enteroctopus dofleini | O97020 | - |
- |
Gallus gallus | O73685 | - |
- |
Homo sapiens | - |
- |
- |
Homo sapiens | Q15835 | - |
- |
Mus musculus | - |
- |
- |
Oryzias latipes | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | autophosphorylation sites of RK, major sites are Ser-488 and Thr-489, minor site is Ser-21 | Bos taurus |
phosphoprotein | autophosphorylation sites of RK, major sites are Ser-488 and Thr-489, minor site is Ser-21 | Homo sapiens |
side-chain modification | - |
Rattus norvegicus |
side-chain modification | GRK1 is geranylgeranylated ex vivo | Gallus gallus |
side-chain modification | native enzyme is farnesylated in vitro and in vivo | Bos taurus |
side-chain modification | prenylated and carboxyl-methylated at Cys-558 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | retina | Mus musculus | - |
eye | retina | Homo sapiens | - |
eye | retina | Bos taurus | - |
eye | retina | Oryzias latipes | - |
eye | retina | Gallus gallus | - |
eye | retina | Enteroctopus dofleini | - |
eye | retina | Doryteuthis pealeii | - |
pineal gland | - |
Bos taurus | - |
pineal gland | - |
Gallus gallus | - |
pineal gland | GRK1 expression | Homo sapiens | - |
pineal gland | GRK1 expression | Rattus norvegicus | - |
retina | - |
Bos taurus | - |
retina | - |
Homo sapiens | - |
retina | in rod and cone photoreceptors | Mus musculus | - |
retina | in rod and cone photoreceptors | Homo sapiens | - |
retina | in rod and cone photoreceptors | Gallus gallus | - |
retina | retina-specific expression | Enteroctopus dofleini | - |
retina | retina-specific expression | Doryteuthis pealeii | - |
retina | expressed exclusively in rods | Oryzias latipes | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + peptide | - |
Bos taurus | ADP + phosphopeptide | - |
? | |
ATP + rhodopsin | - |
Mus musculus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Homo sapiens | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Rattus norvegicus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Oryzias latipes | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Gallus gallus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Enteroctopus dofleini | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | - |
Doryteuthis pealeii | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | regulation of GRK1 | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | highly specific for photobleached rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | highly specific for photobleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | highly specific for photobleached rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | highly specific for photobleached rhodopsin | Enteroctopus dofleini | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | highly specific for photobleached rhodopsin | Doryteuthis pealeii | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | preferred substrate: photobleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | preferred substrate: photobleached rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | phosphorylation sites of photolyzed rhodopsin | Mus musculus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | phosphorylation sites of photolyzed rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | high-gain phosphorylation of rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | domain structure | Bos taurus | ADP + phosphorhodopsin | - |
? |