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Literature summary for 2.7.11.14 extracted from
- A novel form of rhodopsin kinase from chicken retina and pineal gland (1999), FEBS Lett., 454, 115-121.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GRK1 from retina and pineal gland is cloned and sequenced | Gallus gallus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C588S | unprenylated mutant | Bos taurus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6 | - |
rhodopsin | farnesylated GRK1 | Bos taurus |  |
| 9 | - |
rhodopsin | C588S mutant GRK1 | Bos taurus | |
| 30 | - |
rhodopsin | geranylgeranylated GRK1 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-bound | Bos taurus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Bos taurus | |
| Mg2+ | - |
Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid sequence | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | Bos taurus | - |
ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Gallus gallus | important enzyme of phototransduction | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Gallus gallus | light-dependent initiating of deactivation of rhodopsin | ADP + phosphorhodopsin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Gallus gallus | O73685 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | native enzyme is farnesylated in vitro and in vivo | Bos taurus |
| side-chain modification | GRK1 contains a C-terminal consensus sequence for geranylgeranylation | Gallus gallus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from whole retina | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | retina | Bos taurus | - |
| eye | retina | Gallus gallus | - |
| pineal gland | - |
Bos taurus | - |
| pineal gland | young and adult | Gallus gallus | - |
| pineal gland | expression of retinal GRK1 | Gallus gallus | - |
| retina | - |
Bos taurus | - |
| retina | in rod and cone photoreceptors | Gallus gallus | - |
| retina | cone-dominant retina | Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | - |
Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | phosphorylates bovine rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | phosphorylates bovine rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | highly specific for photobleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | highly specific for photobleached rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | important enzyme of phototransduction | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | light-dependent initiating of deactivation of rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Bos taurus |
| ? | x * about 61000, SDS-PAGE | Gallus gallus |
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Release 2023.1 (January 2023)
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