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Literature summary for 2.7.11.14 extracted from
- Ca2+-dependent control of rhodopsin phosphorylation: Recoverin and rhodopsin kinase (2002), Adv. Exp. Med. Biol., 514, 69-99.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| rhodopsin | RK normally exists in an inactive resting state and is only activated following interaction with photoactivated rhodopsin | Bos taurus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA encoding RK is characterized and sequenced, 561 amino acids protein | Bos taurus |
| RK gene encodes a 564 amino acids polypeptide | Homo sapiens |
| RK gene is located on chromosome 13q34 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S488A | autophosphorylation site mutant with increased activity for the phosphorylation of rhodopsin in the dark | Bos taurus |
| S489A | autophosphorylation site mutant with increased activity for the phosphorylation of rhodopsin in the dark | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| recoverin | ATP inhibits and ADP enhances the RK-recoverin interaction, inhibition mechanism; Ca2+-dependent inhibition | Bos taurus | |
| recoverin | Ca2+-dependent inhibition | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid sequence shows high degree of homology to beta-adrenergic receptor kinase primary structure | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | Homo sapiens | - |
ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Rattus norvegicus | - |
ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Bos taurus | deactivation of photoexcited rhodopsin by its phosphorylation by RK, in vivo, since ATP is present, RK exists in an autophosphorylated state | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Mus musculus | the deactivation of photoexcited rhodopsin requires multiple phosphorylations | ADP + phosphorhodopsin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | incubation of purified RK with ATP leads to its autophosphorylation, resulting in the modification of 3 serine residues in positions 21, 488 and 489, the presence of phosphoryl groups may play a regulatory role | Bos taurus |
| side-chain modification | - |
Bos taurus |
| side-chain modification | incorporation of a farnesyl moiety at the C-terminal cysteine residue of the mature protein | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | retina | Mus musculus | - |
| eye | retina | Homo sapiens | - |
| eye | retina | Bos taurus | - |
| retina | - |
Homo sapiens | - |
| retina | rod cell outer segment | Mus musculus | - |
| retina | rod cell outer segment | Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + peptide | - |
Bos taurus | ADP + phosphopeptide | - |
? | |
| ATP + rhodopsin | - |
Homo sapiens | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | - |
Rattus norvegicus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | light-dependent phosphorylation | Mus musculus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | light-dependent phosphorylation | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | phosphorylation sites of bleached rhodopsin, hierarchical order | Mus musculus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | preferred substrate: light-activated form of rhodopsin, i.e. metarhodopsin II | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | RK normally exists in an inactive resting state and is only activated following interaction with photoactivated rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | high-gain phosphorylation of rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | deactivation of photoexcited rhodopsin by its phosphorylation by RK, in vivo, since ATP is present, RK exists in an autophosphorylated state | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | the deactivation of photoexcited rhodopsin requires multiple phosphorylations | Mus musculus | ADP + phosphorhodopsin | - |
? | |
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