Literature summary for 2.7.11.13 extracted from

Kwak, H.J.; Park, K.M.; Choi, H.E.; Lim, H.J.; Park, J.H.; Park, H.Y.
The cardioprotective effects of zileuton, a 5-lipoxygenase inhibitor, are mediated by COX-2 via activation of PKC delta (2010), Cell. Signal., 22, 80-87.

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Activating Compound

Activating Compound	Comment	Organism	Structure
zileuton	zileuton acts as a PKC delta activator, causing it to translocate from the cytosol to nucleus, the activation is inhibited by rottlerin	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
rottlerin	PKC delta-specific inhibitor	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
nucleus	-	Rattus norvegicus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	-	Rattus norvegicus	-
H9c2 cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PKC delta	isoform	Rattus norvegicus

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Release 2023.1 (January 2023)