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Literature summary for 2.7.11.13 extracted from

  • Alfa Cisse, M.; Louis, K.; Braun, U.; Mari, B.; Leitges, M.; Slack, B.E.; Fisher, A.; Auberger, P.; Checler, F.; Vincent, B.
    Isoform-specific contribution of protein kinase C to prion processing (2008), Mol. Cell. Neurosci., 39, 400-410.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
additional information the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
additional information the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
phorbol-ester-12-13-dibutyrate
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells and human-derived rhabdhomyosarcoma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GF109203X inhibits all PKC isozymes, except PKCmu Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17252
-
-
Homo sapiens Q02156
-
-
Homo sapiens Q05513
-
-
Homo sapiens Q05655
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ADAM17
-
Homo sapiens ADP + phosphorylated ADAM17
-
?

Synonyms

Synonyms Comment Organism
PKCalpha isozyme Homo sapiens
PKCdelta isozyme Homo sapiens
PKCepsilon isozyme Homo sapiens
PKCzeta isozyme Homo sapiens