Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) | Homo sapiens | |
additional information | the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) | Homo sapiens | |
additional information | the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) | Homo sapiens | |
phorbol-ester-12-13-dibutyrate | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells and human-derived rhabdhomyosarcoma cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GF109203X | inhibits all PKC isozymes, except PKCmu | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17252 | - |
- |
Homo sapiens | Q02156 | - |
- |
Homo sapiens | Q05513 | - |
- |
Homo sapiens | Q05655 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ADAM17 | - |
Homo sapiens | ADP + phosphorylated ADAM17 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKCalpha | isozyme | Homo sapiens |
PKCdelta | isozyme | Homo sapiens |
PKCepsilon | isozyme | Homo sapiens |
PKCzeta | isozyme | Homo sapiens |