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Literature summary for 2.7.11.13 extracted from

  • Nawaratne, R.; Gray, A.; Jorgensen, C.H.; Downes, C.P.; Siddle, K.; Sethi, J.K.
    Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation (2006), Mol. Endocrinol., 20, 1838-1852.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
diacylglycerol
-
 Rattus norvegicus
additional information no activation by C2 ceramide or chronic insulin treatment Rattus norvegicus
phorbol 12-myristate 13-acetate stimulates IRS1 Ser24 phosphorylation in vivo Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Gö6976 an inhibitor of isozymes cPKCalpha, -beta, and -my Rattus norvegicus
Gö6983 an inhibitor of isozyme PKCbeta, but not of PKCmy Rattus norvegicus
rottlerin a selective inhibitor of nPKCdelta and PKCtheta Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + insulin receptor substrate 1 Rattus norvegicus phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview ADP + phosphorylated insulin receptor substrate 1
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 several PKC isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture NIH/hIR/rIRS1cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + insulin receptor substrate 1 phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview Rattus norvegicus ADP + phosphorylated insulin receptor substrate 1
-
 ?
ATP + insulin receptor substrate 1 a bona fide substrate for conventional isozymes PKCalpha, PKCzeta, and PKCdelta, phosphorylation of IRS1 at Ser24 in the N-terminal pleckstrin homology domain of IRS1, additionally isozyme PKCalpha is indirectly involved in Ser307 and Ser612 phosphorylation Rattus norvegicus ADP + phosphorylated insulin receptor substrate 1
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus