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Literature summary for 2.7.11.13 extracted from

  • Abeywickrama, C.; Rotenberg, S.A.; Baker, A.D.
    Inhibition of protein kinase C by dequalinium analogues: structure-activity studies on head group variations (2006), Bioorg. Med. Chem., 14, 7796-7803.
    View publication on PubMed
Search for more literature for 2.7.11.13

Inhibitors

Inhibitors Comment Organism Structure
1,1'-(1,10-decanediyl)bis[1-amino isoquinolinium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[2-amino-1-methylbenzimidazolium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[2-methylbenzothiazolium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[2-methylbenzoxazolium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[2-methylquinolinium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[4-amino-2-methyl quinolinium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[4-aminoquinolinium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[4-N,N,dimethylaminoquinolinium] diiodide
-
 Homo sapiens
1,1'-(1,10-decanediyl)bis[quinolinium] diiodide
-
 Homo sapiens
1,1'-decane-1,10-diylbis(4-aminopyridinium) diiodide
-
 Homo sapiens
1,1'-decane-1,10-diylbis[4-(dimethylamino)pyridinium]
-
 Homo sapiens
1,6-bis[N-(1-methylquinolinium-2-methyl)amino]-hexane diiodide
-
 Homo sapiens
4-amino-1,2-dimethylquinolinium
-
 Homo sapiens
4-amino-1-decyl-2-methylquinolinium iodide
-
 Homo sapiens
additional information inhibition of PKC by dequalinium analogues of bis-quaternary dequalinium salts, structure-activity studies on head group variations, overview, Mulliken charges on N1 of the model compounds used for correlation, overview Homo sapiens
N,N,N,N',N',N'-hexaethyldecane-1,10-diaminium
-
 Homo sapiens
N-cyclohexa-1,3-dien-1-yl-N,N,N',N',N'-pentaphenyldecane-1,10-diaminium
-
 Homo sapiens
propidiumiodide
-
 Homo sapiens
safranine O
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme pKCalpha
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RFARKGSLRQKNV
-
 Homo sapiens ADP + phosphorylated RFARKGSLRQKNV
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl quinolinium] diiodide
0.014
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[2-amino-1-methylbenzimidazolium] diiodide
0.016
-
 pH 7.4 Homo sapiens propidiumiodide
0.017
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[2-methylbenzothiazolium] diiodide
0.022
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[2-methylquinolinium] diiodide
0.029
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[4-N,N,dimethylaminoquinolinium] diiodide
0.03
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[4-aminoquinolinium] diiodide
0.03
-
 pH 7.4 Homo sapiens 1,6-bis[N-(1-methylquinolinium-2-methyl)amino]-hexane diiodide
0.03
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[1-amino isoquinolinium] diiodide
0.036
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[2-methylbenzoxazolium] diiodide
0.048
-
 pH 7.4 Homo sapiens safranine O
0.072
-
 pH 7.4 Homo sapiens 1,1'-(1,10-decanediyl)bis[quinolinium] diiodide
0.094
-
 pH 7.4 Homo sapiens N-cyclohexa-1,3-dien-1-yl-N,N,N',N',N'-pentaphenyldecane-1,10-diaminium
0.112
-
 pH 7.4 Homo sapiens 1,1'-decane-1,10-diylbis(4-aminopyridinium) diiodide
0.117
-
 pH 7.4 Homo sapiens 4-amino-1-decyl-2-methylquinolinium iodide
0.231
-
 pH 7.4 Homo sapiens 1,1'-decane-1,10-diylbis[4-(dimethylamino)pyridinium]
0.25
-
 pH 7.4 Homo sapiens N,N,N,N',N',N'-hexaethyldecane-1,10-diaminium
3.59
-
 pH 7.4 Homo sapiens 4-amino-1,2-dimethylquinolinium