Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Diacylglycerols | activate PKC isozymes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Go6976 | - |
Mus musculus | |
rottlerin | specific inhibitor of isozyme PKCdelta | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates, required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + vasodilator-stimulated phosphoprotein | Mus musculus | phosphorylation at Ser157 | ADP + phosphorylated vasodilator-stimulated phosphoprotein | - |
? | |
additional information | Mus musculus | PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
PKC isoforms can be split into three groups: conventional, novel and atypical, overview | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + vasodilator-stimulated phosphoprotein | phosphorylation at Ser157 | Mus musculus | ADP + phosphorylated vasodilator-stimulated phosphoprotein | - |
? | |
additional information | PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | PKCs form a family of related serine/threonine kinases that are part of the AGC-type kinase, kinase G/protein kinase C-family kinase, superfamily | Mus musculus |
PKC | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |