Literature summary for 2.7.11.13 extracted from

Chen, J.S.; Exton, J.H.
Regulation of phospholipase D2 activity by protein kinase Calpha (2004), J. Biol. Chem., 279, 22076-22083.

Search for more literature for 2.7.11.13

Activating Compound

Activating Compound	Comment	Organism	Structure
4beta-phorbol 12-myristate 13-acetate	activates PKCalpha-mediated activation of phospholipase D	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bisindolylmaleimide	strong inhibition of PKCalpha	Homo sapiens
Gö 6976	slight inhibition of PKCalpha	Homo sapiens
Ro-31-8220	strong inhibition of PKCalpha	Homo sapiens
rottlerin	slight inhibition of PKCalpha	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	translocation	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	recombinant PKCalpha	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + phospholipase D1	phosphorylation by PKC	Homo sapiens	ADP + phosphorylated phospholipase D1	-	?
ATP + phospholipase D2	phosphorylation by PKCalpha	Homo sapiens	ADP + phosphorylated phospholipase D2	-	?
additional information	activation of phospholipase D2 by 4beta-phorbol 12-myristate 13-acetate-induced PKCalpha does not require phosphorylation, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PKCalpha	-	Homo sapiens
protein kinase Calpha	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)