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Literature summary for 2.7.11.13 extracted from
- Regulation of endothelial nitric oxide synthase by protein kinase C (2003), J. Biochem., 133, 773-781.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dioleoylglycerol | - |
Bos taurus |  |
| phorbol 12-myristate 13-acetate | - |
Bos taurus | |
| phosphatidylserine | - |
Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Bos taurus | |
| Mg2+ | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + endothelial nitric oxide synthase | Bos taurus | the enzyme is responsible for the negative regulation of endothelial nitric oxide synthase, a key enzyme in nitric oxide-mediated signal transduction, phosphorylation reduces the affinity of nitric oxide synthase for calmodulin | ADP + phosphorylated endothelial nitric oxide synthase | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Bos taurus | - |
| brain | - |
Bos taurus | - |
| endothelium | aortic | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + calmodulin | phosphorylation at Thr497 in the calmodulin-binding domain, binding is competitive to substrate endothelial nitric oxide synthase | Bos taurus | ADP + phosphorylated calmodulin | - |
? | |
| ATP + endothelial nitric oxide synthase | the enzyme is responsible for the negative regulation of endothelial nitric oxide synthase, a key enzyme in nitric oxide-mediated signal transduction, phosphorylation reduces the affinity of nitric oxide synthase for calmodulin | Bos taurus | ADP + phosphorylated endothelial nitric oxide synthase | - |
? | |
| ATP + endothelial nitric oxide synthase | phosphorylation at Thr497 in the calmodulin-binding domain, binding is competitive to substrate calmodulin | Bos taurus | ADP + phosphorylated endothelial nitric oxide synthase | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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