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Literature summary for 2.7.11.13 extracted from
- Pathway illuminated: visualizing protein kinase C signaling (2003), IUBMB Life, 55, 653-660.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| diacylglycerol | required, second messenger involved in PKC regulation | Mus musculus |  |
| diacylglycerol | required, second messenger involved in PKC regulation | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GFP-tagged PKC | Mus musculus |
| expression of GFP-tagged PKC | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of PKC isozyme-deletion mutant mice leading to important metabolic deficiencies in the mutant mice | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting | Mus musculus | 16020 | - |
| membrane | bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent | Mus musculus | |
| Ca2+ | required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview | ? | - |
? | |
| additional information | Mus musculus | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
several isozymes | - |
| Mus musculus | - |
several isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | PKC domain composition | Mus musculus |
| More | PKC domain composition | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Mus musculus |
| PKC | - |
Homo sapiens |
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