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Literature summary for 2.7.11.13 extracted from

  • Guo, B.; Su, T.T.; Rawlings, D.J.
    Protein kinase C family functions in B-cell activation (2004), Curr. Opin. Immunol., 16, 367-373.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of PKC isozyme, e.g. PKCzeta-deficient or PKCdelta-deficient, knockout mice, construction of PKCbeta-deficient B-cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Btk Mus musculus specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview ADP + phosphorylated Btk
-
?
additional information Mus musculus PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
several isozymes
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of PKCny leads to its activation in response to B-cell receptor engagement in subcellular compartment redistribution Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-cell PKC isozyme expression patterns Mus musculus
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B-lymphocyte
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Btk specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview Mus musculus ADP + phosphorylated Btk
-
?
ATP + Btk specific phosphorylation of the tyrosine protein kinase at Ser180 within the Tec-homology domain Mus musculus ADP + phosphorylated Btk
-
?
additional information PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance Mus musculus ?
-
?
additional information PKC interacts with CARMA-1, involved in signaling from PKC to NF-kappaB Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
More PKC occurs in multiple isozymes, designated as classical, novel, and atypical isozymes, belonging to the PKC family Mus musculus
PKC
-
Mus musculus