Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of PKC isozyme, e.g. PKCzeta-deficient or PKCdelta-deficient, knockout mice, construction of PKCbeta-deficient B-cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Btk | Mus musculus | specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview | ADP + phosphorylated Btk | - |
? | |
additional information | Mus musculus | PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
several isozymes | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of PKCny leads to its activation in response to B-cell receptor engagement in subcellular compartment redistribution | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | PKC isozyme expression patterns | Mus musculus | - |
B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Btk | specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview | Mus musculus | ADP + phosphorylated Btk | - |
? | |
ATP + Btk | specific phosphorylation of the tyrosine protein kinase at Ser180 within the Tec-homology domain | Mus musculus | ADP + phosphorylated Btk | - |
? | |
additional information | PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance | Mus musculus | ? | - |
? | |
additional information | PKC interacts with CARMA-1, involved in signaling from PKC to NF-kappaB | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | PKC occurs in multiple isozymes, designated as classical, novel, and atypical isozymes, belonging to the PKC family | Mus musculus |
PKC | - |
Mus musculus |