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Literature summary for 2.7.11.13 extracted from

  • Barman, S.A.; Zhu, S.; White, R.E.
    Protein kinase C inhibits BKCa channel activity in pulmonary arterial smooth muscle (2004), Am. J. Physiol., 286, L149-155.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phorbol 12-myristate 13-acetate
-
Rattus norvegicus
thymeleatoxin
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
GΓΆ-6976 selective inhibition of isozymes PKCalpha, PKCbeta, and PKC-my Rattus norvegicus
rottlerin selective inhibition of isozyme PKCdelta Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus some PKC isozymes inhibit BKCa channel activity in pulmonary arterial smooth muscle via inhibition of cAMP-induced activation of the BKCa channel ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery pulmonary Rattus norvegicus
-
blood vessel arterial pulmonary Rattus norvegicus
-
lung
-
Rattus norvegicus
-
smooth muscle pulmonary arterial Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information some PKC isozymes inhibit BKCa channel activity in pulmonary arterial smooth muscle via inhibition of cAMP-induced activation of the BKCa channel Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PKC
-
Rattus norvegicus