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Literature summary for 2.7.11.13 extracted from

  • Sturany, S.; Van Lint, J.; Muller, F.; Wilda, M.; Hameister, H.; Hocker, M.; Brey, A.; Gern, U.; Vandenheede, J.; Gress, T.; Adler, G.; Seufferlein, T.
    Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases (2001), J. Biol. Chem., 276, 3310-3318.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
gastrin physiological activator of PKD2 in human AGS-B cells stably transfected with the CCK(B)/gastrin receptor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
x * 105000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZL6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phorbol 12,13-dibutyrate in the presence of dioleoylphosphatidylserine stimulates the autophosphorylation of PKD2 in a synergistic fashion. Phorbol esters also stimulate autophosphorylation of PKD2 in intact cells, C-terminal Ser876 is an in vivo phosphorylation site within PKD2 that is correlated with the activation status of the kinase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell AGS-B cell Homo sapiens
-
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1 PKD2 activated by phorbol esters efficiently phosphorylate the exogenous substrate histone H1 Homo sapiens ADP + phosphorylated histone H1
-
?

Subunits

Subunits Comment Organism
? x * 105000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PKD2
-
Homo sapiens
protein kinase C, D2 type
-
Homo sapiens
protein kinase D2
-
Homo sapiens