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Literature summary for 2.7.11.12 extracted from

  • Leutner, S.; Beckmann, S.; Grevelding, C.G.
    Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni (2011), An. Acad. Bras. Cienc., 83, 637-648.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
SmcGK1, DNA and amino acid sequence determination and analysis, phylogenetic analysis and sequence comparisons, SmcGK1 is gender-independently transcribed in adult schistosomes, expression of the gene is controlled at the post-transcriptional level Schistosoma mansoni

Inhibitors

Inhibitors Comment Organism Structure
Rp-8-pCPT-cGMPS a cGMP analogue Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni E7BBH9 Liberian isolate
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Source Tissue

Source Tissue Comment Organism Textmining
gonad of male and female worms, SmcGK1 shows a gonad-preferential expression profile in both genders Schistosoma mansoni
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additional information in situ hybridizations and immunoaffinity histochemic detection, overview Schistosoma mansoni
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vitellarium
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 Schistosoma mansoni
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Synonyms

Synonyms Comment Organism
cGKI
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 Schistosoma mansoni
cyclic guanosine-3', 5'-monophosphate-dependent protein kinase
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 Schistosoma mansoni

General Information

General Information Comment Organism
evolution cGMP-dependent protein kinases belong to the group of serine/threonine kinases. The complete amino acid sequence of SmcGK1 indicates a greater similarity to type II cGKsof other organisms, but the sequence of SmcGK1 lacks a myristoylation motive typically found in mammalian membrane-bound cGKII, the homology to mammalian cGKII is mainly due to a high similarity of the kinase domains. SmcGK1 seems to occupy an intermediate position with respect to cGK classifications Schistosoma mansoni
malfunction enzyme inhibition leads to a multifaceted phenotype including slow motion, oocyte congestion, and reduced egg production Schistosoma mansoni
physiological function possible role of SmcGK1 during sexual development of schistosomes Schistosoma mansoni