Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.12 extracted from

  • Takahashi, S.; Lin, H.; Geshi, N.; Mori, Y.; Kawarabayashi, Y.; Takami, N.; Mori, M.X.; Honda, A.; Inoue, R.
    Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6 (2008), J. Physiol., 586, 4209-4223.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP 0.1 mM Homo sapiens
8-bromo-cGMP 0.1 mM Rattus norvegicus
additional information the activity of transient receptor potential channel 6 channels is markedly suppressed by PKG activation Homo sapiens
additional information the activity of transient receptor potential channel 6 channels is markedly suppressed by PKG activation Rattus norvegicus
nitric oxide
-
Homo sapiens
nitric oxide
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
DT3
-
Homo sapiens
DT3
-
Rattus norvegicus
KT-5823
-
Homo sapiens
KT-5823
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A7r5 cell
-
Rattus norvegicus
-
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + transient receptor potential channel 6 PKG phosphorylation is reduced in transient receptor potential channel 6 mutant T69A Homo sapiens ADP + phosphorylated transient receptor potential channel 6
-
?
ATP + transient receptor potential channel 6 PKG phosphorylation is reduced in transient receptor potential channel 6 mutant T69A Rattus norvegicus ADP + phosphorylated transient receptor potential channel 6
-
?

Synonyms

Synonyms Comment Organism
cGMP-protein kinase G
-
Homo sapiens
cGMP-protein kinase G
-
Rattus norvegicus
PKG Ialpha
-
Homo sapiens
PKG Ialpha
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
cGMP dependent Homo sapiens
cGMP dependent Rattus norvegicus