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Literature summary for 2.7.11.12 extracted from

  • Dawson-Scully, K.; Armstrong, G.A.; Kent, C.; Robertson, R.M.; Sokolowski, M.B.
    Natural variation in the thermotolerance of neural function and behavior due to a cGMP-dependent protein kinase (2007), PLoS ONE, 2, e773.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP PKG activator 8-bromo-cGMP abolishes thermoprotective effect of a prior heat shock Drosophila melanogaster
cGMP
-
 Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
the enzyme is encoded by the foraging gene for which shows polymorphisms associated with the allelic variation in for Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
KT5823 a specific PKG inhibitor, PKG inhibition induces rapid thermotolerance of neural circuitry Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster reduced enzyme activity leads to increased thermotolerance of synaptic transmission at the larval neuromuscular junction, PKG and the for gene polymorphism associated with the allelic variation in for may provide populationswith natural variantion in heat stress tolerance, the for gene function in behaviour is conserved across most organisms, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
 gene for
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Drosophila melanogaster
-
muscle
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information reduced enzyme activity leads to increased thermotolerance of synaptic transmission at the larval neuromuscular junction, PKG and the for gene polymorphism associated with the allelic variation in for may provide populationswith natural variantion in heat stress tolerance, the for gene function in behaviour is conserved across most organisms, overview Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster