Literature summary for 2.7.11.12 extracted from

Hou, Y.; Wong, E.; Martin, J.; Schoenlein, P.V.; Dostmann, W.R.; Browning, D.D.
A role for cyclic-GMP dependent protein kinase in anoikis (2006), Cell. Signal., 18, 882-888.

Search for more literature for 2.7.11.12

Activating Compound

Activating Compound	Comment	Organism	Structure
8-bromo-cGMP	-	Homo sapiens
cGMP	-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme inhibition by a dominant negative PKG construct G1alphaR-GFP, enzyme inhibition blocks apoptosis in suspended CCD841 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
DT-2 peptide	a HIV tat peptide sequence, blocks type 1 PKG	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + vasodilator stimulated phosphoprotein	Homo sapiens	-	ADP + phosphorylated vasodilator stimulated phosphoprotein	-	?
additional information	Homo sapiens	the enzyme is involved in development of anoikis, an essential process in which a loss of adhesion to the substratum alters intracellular signaling pathways that lead to apoptosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes alpha and beta of type 1 PKG	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CCD-841 cell	colonic epithelial cell line	Homo sapiens	-
colon	-	Homo sapiens	-
epithelial cell	-	Homo sapiens	-
additional information	no expression of PKG in colon carcinoma cell lines SW480 and SW620	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + vasodilator stimulated phosphoprotein	-	Homo sapiens	ADP + phosphorylated vasodilator stimulated phosphoprotein	-	?
additional information	the enzyme is involved in development of anoikis, an essential process in which a loss of adhesion to the substratum alters intracellular signaling pathways that lead to apoptosis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cyclic-GMP dependent protein kinase	-	Homo sapiens
PKG	-	Homo sapiens
type 1 PKG	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)