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Literature summary for 2.7.11.12 extracted from

  • Danielewski, O.; Schultess, J.; Smolenski, A.
    The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I (2005), Thromb. Haemost., 93, 319-325.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-pCPT-CGMP i.e. i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, cGMP analogue, membrane-permeable Homo sapiens
cGMP dependent on Homo sapiens
additional information cGKI activity is induced by NO via increased cGMP production Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Rp-8-pCPT-cGMP i.e. Rp-8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, cGKI inhibitor, reverses the NO effects Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the NO/cGMP pathway including inhibits Ca2+-dependent and turbulence-induced Rap 1 activation in human platelets mediated by cGKI in platelets and megakaryocytes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-
MEG-01 cell megakaryocyte cell line Homo sapiens
-
megakaryocyte MEG-01 cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + VASP
-
 Homo sapiens ADP + VAS(P)P
-
 ?
additional information the NO/cGMP pathway including inhibits Ca2+-dependent and turbulence-induced Rap 1 activation in human platelets mediated by cGKI in platelets and megakaryocytes Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cGKI
-
 Homo sapiens
cGMP-dependent protein kinase I
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens