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Literature summary for 2.7.11.12 extracted from

  • Bois, P.R.; Brochard, V.F.; Salin-Cantegrel, A.V.; Cleveland, J.L.; Grosveld, G.C.
    FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion (2005), Mol. Cell. Biol., 25, 7645-7656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP dependent on Mus musculus
FoxO1a directly activates enzyme expression binding to DNA in skeletal muscle Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information primary myoblast of enzyme-deficient mice mutants show excessive cell fusion Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + FoxO1a Mus musculus interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis ADP + phosphorylated FoxO1a
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
myoblast primary Mus musculus
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myocyte
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 Mus musculus
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myotube
-
 Mus musculus
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skeletal muscle cell
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + FoxO1a interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis Mus musculus ADP + phosphorylated FoxO1a
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 ?
ATP + FoxO1a enzyme expression is activated by FoxO1a which is then phosphorylated by cGKI for feedback inhibition of FoxO1a DNA binding, phosphorylation of Ser152-155 and Ser184, and weakly of Ser266 and Ser268 Mus musculus ADP + phosphorylated FoxO1a
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 ?

Synonyms

Synonyms Comment Organism
cGKI
-
 Mus musculus
cyclic GMP-dependent kinase I
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus