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Literature summary for 2.7.11.12 extracted from

  • West, G.A.; Meno, J.R.; Nguyen, T.S.; Ngai, A.C.; Simard, J.M.; Winn, H.R.
    cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intracerebral arterioles (2003), J. Cardiovasc. Pharmacol., 41, 444-451.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-Br-cGMP selective for PKG Rattus norvegicus
adenosine adenosine-induced vasodilation in cerebral microvessesls involves cGMP and cGMP-dependent protein kinase Rattus norvegicus
cGMP selective for PKG Rattus norvegicus
cgs-21680
-
 Rattus norvegicus
sodium nitroprusside i.e. SNP, selective for PKG Rattus norvegicus
Sp-8-pCPT-cGMPS cyclic guanosine monophosphate-dependent protein kinase activator, selective for PKG Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one
-
 Rattus norvegicus
N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide
-
 Rattus norvegicus
Rp-8-pCTP-cGMPS selective for PKG Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
arteriole cerebral, microvascular, isolated from cortical vessels Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in vasodilation of arterioles measured in passive diameter Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in vivo assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.6 assay at, study of pH responsiveness of asteriole enzymes in vivo Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus