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Literature summary for 2.7.11.12 extracted from

  • Vaandrager, A.B.; Hogema, B.M.; de Jonge, H.R.
    Molecular properties and biological functions of cGMP-dependent protein kinase II (2005), Front. Biosci., 10, 2150-2164.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP cGK I and cGK II contain a high and a low affinity binding site for cGMP with opposite orientation in cGK II compared to cGK I Mammalia
additional information isozymes cGK I and cGK II exhibit different affinity for cGMP analogues, overview Mammalia

Inhibitors

Inhibitors Comment Organism Structure
additional information cGK II contains an autoinhibitory region Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane isozyme cGK II bound by a myristoyl moiety Mammalia 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia isozymes cGK I and cGK II are functionally distinct, isozyme cGK II is involved in regulation of electrolyte and water secretion by epithelial tissues in response to luminocrinic hormones guanylin and uroguanylin and in the secretory diarrhea provoked by heat-stable enterotoxins, isozyme cGK II also plays a role in the regulation of endochondral ossification by C-type natriuretic peptide, in renin secretion by the kidney, aldosterone secretion by the adrenal, and adjustment of the biological clock ?
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 ?

Organism

Organism UniProt Comment Textmining
Mammalia
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 2 genes encoding isozymes cGK I and cGK II, respectively
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Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme cGK II Mammalia
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intestine isozyme cGK II Mammalia
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kidney isozyme cGK II Mammalia
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additional information isozymes cGK I and cGK II show different tissue distribution and expression patterns Mammalia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozymes cGK I and cGK II are functionally distinct, isozyme cGK II is involved in regulation of electrolyte and water secretion by epithelial tissues in response to luminocrinic hormones guanylin and uroguanylin and in the secretory diarrhea provoked by heat-stable enterotoxins, isozyme cGK II also plays a role in the regulation of endochondral ossification by C-type natriuretic peptide, in renin secretion by the kidney, aldosterone secretion by the adrenal, and adjustment of the biological clock Mammalia ?
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 ?

Subunits

Subunits Comment Organism
More domain structure of cGK II compared to the structure of cGK Ialpha and beta, cGK II is composed of an N-terminal regulatory domain, a dimerization, an autoinhibitory region, two cGMP-binding domains, and a C-terminal catalytic domain Mammalia

Synonyms

Synonyms Comment Organism
cGK I
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 Mammalia
cGK II
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 Mammalia
cGMP-dependent protein kinase I
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 Mammalia
cGMP-dependent protein kinase II
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 Mammalia
type I cGMP-dependent protein kinase
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 Mammalia
Type II cGMP-dependent protein kinase
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 Mammalia