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Literature summary for 2.7.11.12 extracted from

  • Chang, S.; Hypolite, J.A.; Velez, M.; Changolkar, A.; Wein, A.J.; Chacko, S.; DiSanto, M.E.
    Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits (2004), Am. J. Physiol., 287, R950-960.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP dependent on Oryctolagus cuniculus
additional information high glucose levels induce NO-induced stimulation of cGMP production and increase PKG-1 activity Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme activity is reduced in diabetic rabbits Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus PKG-1 is involved in NO-induced cGMP-mediated increase in corpus cavernosum smooth muscle relaxation and penile erection, enzyme disfunction can cause erectile dysfunction, diabetes reduces corpus cavernosum smooth muscle relaxation ?
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 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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 wild-type and diabetic male New Zealand White rabbits, isozymes PKG-1alpha and PKG-1beta
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Source Tissue

Source Tissue Comment Organism Textmining
aorta high expression of isozymes PKG-1alpha and PKG-1beta Oryctolagus cuniculus
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corpus cavernosum corpus cavernosum smooth muscle, high expression of isozymes PKG-1alpha and PKG-1beta, corpus cavernosum smooth muscle of diabetic rabbits show reduced expression of isozyme PKG-1alpha Oryctolagus cuniculus
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heart low expression of isozymes PKG-1alpha and PKG-1beta Oryctolagus cuniculus
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smooth muscle corpus cavernosum smooth muscle, high expression of isozymes PKG-1alpha and PKG-1beta, corpus cavernosum smooth muscle of diabetic rabbits show reduced expression of isozyme PKG-1alpha Oryctolagus cuniculus
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urinary bladder expression of isozymes PKG-1alpha and PKG-1beta Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PKG-1 is involved in NO-induced cGMP-mediated increase in corpus cavernosum smooth muscle relaxation and penile erection, enzyme disfunction can cause erectile dysfunction, diabetes reduces corpus cavernosum smooth muscle relaxation Oryctolagus cuniculus ?
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 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase-1
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 Oryctolagus cuniculus
PKG-1
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 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus