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Literature summary for 2.7.11.11 extracted from

  • Srivastava, A.K.; McDonald, L.R.; Cembran, A.; Kim, J.; Masterson, L.R.; McClendon, C.L.; Taylor, S.S.; Veglia, G.
    Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling (2014), Structure, 22, 1735-1743.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
Y204A the mutation desynchronizes the opening and closing of the active cleft without changing the enzyme's structure, rendering it catalytically inefficient Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + phosphorylated protein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P05132
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + phosphorylated protein
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase A
-
 Mus musculus
PKA-C catalytic subunit Mus musculus