Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | alone increases activity, which is further increased by the addition of forskolin plus dibutyryl-cAMP and phosphodiesterase inhibitor IBMX | Rattus norvegicus | |
Lactic acid | increases intracellular cAMP, pCREB and PKA activity | Rattus norvegicus | |
additional information | no intracellular activating effect by sodium lactate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KT5720 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [cystic fibrosis transmembrane conductance regulator protein] | Rattus norvegicus | - |
ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein] | - |
? | |
ATP + [cystic fibrosis transmembrane conductance regulator protein] | Rattus norvegicus Sprague-Dawley | - |
ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
L-6 myoblast cell | - |
Rattus norvegicus | - |
myocyte | - |
Rattus norvegicus | - |
skeletal muscle | soleus muscle | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [cystic fibrosis transmembrane conductance regulator protein] | - |
Rattus norvegicus | ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein] | - |
? | |
ATP + [cystic fibrosis transmembrane conductance regulator protein] | - |
Rattus norvegicus Sprague-Dawley | ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein] | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of PKA with KT5720 abolishes lactic-acid- or contraction-induced ATP release from muscle | Rattus norvegicus |
metabolism | the cAMP/PKA pathway is involved in the signal transduction pathway for cystic fibrosis transmembrane conductance regulator-regulated ATP release from muscle | Rattus norvegicus |
physiological function | cAMP and PKA are involved in the activation of cystic fibrosis transmembrane conductance regulator, CFTR, during muscle contractions or acidosis. CFTR is involved in the release of ATP from the contracting skeletal muscle in vivo, role of intracellular cAMP in stimulating the increase in extracellular ATP at low pH | Rattus norvegicus |