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Literature summary for 2.7.11.11 extracted from

  • Itoh, T.; Abe, K.; Hong, J.; Inoue, O.; Pike, V.W.; Innis, R.B.; Fujita, M.
    Effects of cAMP-dependent protein kinase activator and inhibitor on in vivo rolipram binding to phosphodiesterase 4 in conscious rats (2010), Synapse, 64, 172-176.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
dibutyryl-cAMP PKA activator Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(Rp)-adenosine-3',5'-cyclic monophosphorothioate PKA inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphodiesterase-4
-
 Rattus norvegicus ADP + phosphorylated phosphodiesterase-4
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase A
-
 Rattus norvegicus
PKA
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
cAMP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function PKA activates phosphodiesterase-4 and increases the sensitivity of phosphodiesterase-4 to inhibition by rolipram Rattus norvegicus