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Literature summary for 2.7.11.11 extracted from

  • Funderud, A.; Aas-Hanssen, K.; Aksaas, A.K.; Hafte, T.T.; Corthay, A.; Munthe, L.A.; Orstavik, S.; Skalhegg, B.S.
    Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA) (2009), Cell. Signal., 21, 274-281.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
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Mus musculus
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Synonyms

Synonyms Comment Organism
protein kinase A Calpha subunit Mus musculus
protein kinase A Cbeta subunit Mus musculus

General Information

General Information Comment Organism
malfunction protein kinase A Calpha and Cbeta ablation both results in a 50% reduction in PKA-specific kinase activity and the level of PKA type I but not PKA type II, PKA subunit Calpha but not Cbeta ablation augments expression of the activation marker CD69 on lymphocytes Mus musculus
physiological function protein kinase A Calpha is required for normal immune cell reactivity Mus musculus