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Literature summary for 2.7.11.11 extracted from

  • de Pina, M.Z.; Vazquez-Meza, H.; Pardo, J.P.; Rendon, J.L.; Villalobos-Molina, R.; Riveros-Rosas, H.; Pina, E.
    Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H2O2 and reactivation by thioredoxin (2008), J. Biol. Chem., 283, 12373-12386.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
dibutyryl-cAMP
-
 Rattus norvegicus
dibutyryl-cAMP
-
 Bos taurus

Protein Variants

Protein Variants Comment Organism
C199A the mutant of the catalytic alpha-subunit in the holoenzyme leads to insensitivity towards H2O2 Rattus norvegicus
C199A the mutant of the catalytic alpha-subunit in the holoenzyme leads to insensitivity towards H2O2 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
H-89
-
 Bos taurus
H-89
-
 Rattus norvegicus
H2O2 H2O2 inhibits activation of PKA, but inhibition can be reverted with dithiothreitol or with thioredoxin reductase plus thioredoxin, H2O2 is ineffective if the PKA holoenzyme is preincubated with cAMP, if added to the catalytic alpha-subunit, which is active independently of cAMP activation, or if the catalytic alpha-subunit is substituted by ist C199A mutant in the reconstituted holoenzyme Bos taurus
H2O2 H2O2 inhibits activation of PKA, but inhibition can be reverted with dithiothreitol or with thioredoxin reductase plus thioredoxin, H2O2 is ineffective if the PKA holoenzyme is preincubated with cAMP, if added to the catalytic alpha-subunit, which is active independently of cAMP activation, or if the catalytic alpha-subunit is substituted by ist C199A mutant in the reconstituted holoenzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Rattus norvegicus
-
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Kemptide
-
 Rattus norvegicus ADP + Kemptide phosphate
-
 ?
ATP + Kemptide
-
 Bos taurus ADP + Kemptide phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Rattus norvegicus
PKA
-
 Bos taurus
protein kinase A
-
 Rattus norvegicus
protein kinase A
-
 Bos taurus
type IIbeta cyclic AMP-dependent protein kinase
-
 Rattus norvegicus
type IIbeta cyclic AMP-dependent protein kinase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Bos taurus
cAMP dependent Rattus norvegicus
cAMP dependent Bos taurus