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Literature summary for 2.7.11.11 extracted from

  • D'Souza, T.; Agarwal, R.; Morin, P.J.
    Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells (2005), J. Biol. Chem., 280, 26233-26240.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on Homo sapiens
additional information forskolin induces PKA activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H-89
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + claudin-3 Homo sapiens high activity in ovarian cancer cells with recombinantly overexpressed claudin-3, phosphorylation of claudin-3 affecting the barrier function with extracellular Ca2+, overview ADP + phosphorylated claudin-3
-
 ?
additional information Homo sapiens no activity with claudin-4 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
2008 cell ovarian cancer cell line Homo sapiens
-
A-2780 cell ovarian cancer cell line Homo sapiens
-
BG-1 cell ovarian cancer cell line Homo sapiens
-
CAOV-3 cell ovarian cancer cell line Homo sapiens
-
HEY cell ovarian cancer cell line Homo sapiens
-
HOSE-B cell immortilized ovarian surface epithelial cell line Homo sapiens
-
IGROV-1 cell ovarian cancer cell line Homo sapiens
-
additional information high PKA activity in ovarian cancer cells Homo sapiens
-
OVCA-420 cell ovarian cancer cell line Homo sapiens
-
OVCA-429 cell ovarian cancer cell line Homo sapiens
-
OVCA-432 cell ovarian cancer cell line Homo sapiens
-
OVCA-433 cell ovarian cancer cell line Homo sapiens
-
OVCAR-2 cell ovarian cancer cell line Homo sapiens
-
OVCAR-3 cell ovarian cancer cell line Homo sapiens
-
OVCAR-4 cell ovarian cancer cell line Homo sapiens
-
OVCAR-5 cell ovarian cancer cell line Homo sapiens
-
UCI-101 cell ovarian cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + claudin-3 high activity in ovarian cancer cells with recombinantly overexpressed claudin-3, phosphorylation of claudin-3 affecting the barrier function with extracellular Ca2+, overview Homo sapiens ADP + phosphorylated claudin-3
-
 ?
ATP + claudin-3 recombinant GST-fusion claudin-3 expressed in Escherichia coli, phosphorylation at Thr192, activity of catalytic PKA subunit Homo sapiens ADP + phosphorylated claudin-3
-
 ?
ATP + claudin-3 S199A recombinant GST-fusion claudin-3 mutant S199A expressed in Escherichia coli, phosphorylation at Thr192, activity of catalytic PKA subunit is lower compared to wild-type claudin-3 Homo sapiens ADP + phosphorylated claudin-3 S199A
-
 ?
additional information no activity with claudin-4 Homo sapiens ?
-
 ?
additional information no activity with claudin-4, poor activity with claudin-3 mutant T192A Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens