Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of the catalytic subunit C in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-89 | selective, but not specific inhibitor of PKA | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + merlin | Homo sapiens | recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin | ADP + phosphorylated merlin | - |
? | |
additional information | Homo sapiens | merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + merlin | recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin | Homo sapiens | ADP + phosphorylated merlin | - |
? | |
ATP + merlin | a membrane/cytoskeleton linker protein, activity of the catalytic subunit C, phosphorylation at the N- and the C-terminus, e.g. at Ser518 | Homo sapiens | ADP + phosphorylated merlin | - |
? | |
additional information | merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclic AMP-dependent protein kinase | - |
Homo sapiens |
PKA | - |
Homo sapiens |
protein kinase A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |