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Literature summary for 2.7.11.11 extracted from

  • Alfthan, K.; Heiska, L.; Gronholm, M.; Renkema, G.H.; Carpen, O.
    Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization (2004), J. Biol. Chem., 279, 18559-18566.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of the catalytic subunit C in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H-89 selective, but not specific inhibitor of PKA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + merlin Homo sapiens recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin ADP + phosphorylated merlin
-
?
additional information Homo sapiens merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + merlin recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin Homo sapiens ADP + phosphorylated merlin
-
?
ATP + merlin a membrane/cytoskeleton linker protein, activity of the catalytic subunit C, phosphorylation at the N- and the C-terminus, e.g. at Ser518 Homo sapiens ADP + phosphorylated merlin
-
?
additional information merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cyclic AMP-dependent protein kinase
-
Homo sapiens
PKA
-
Homo sapiens
protein kinase A
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens