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Literature summary for 2.7.11.11 extracted from
- cAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells (2003), J. Biol. Chem., 278, 8106-8111.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | intracellular amount is controlled by the stimulating steroid hormone adrenocorticotropin ACTH in the adrenal cortex increasing PKA enzyme activity, cAMP induces MKP-1 mRNA and protein expression | Homo sapiens |  |
| dibutyryl-cAMP | induces MKP-1 mRNA and protein expression in H295R cells | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + mitogen-activated protein kinase phosphatase-1 | Homo sapiens | the enzyme enhances steroid hydroxylase CYP17 transcription via mitogen-activated protein kinase phosphatase-1 MKP-1 activation in H295R adrenocortical cells | ADP + phosphorylated mitogen-activated protein kinase phosphatase-1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal cortex | - |
Homo sapiens | - |
| NCI-H295R cell | adrenocortical cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + mitogen-activated protein kinase phosphatase-1 | the enzyme enhances steroid hydroxylase CYP17 transcription via mitogen-activated protein kinase phosphatase-1 MKP-1 activation in H295R adrenocortical cells | Homo sapiens | ADP + phosphorylated mitogen-activated protein kinase phosphatase-1 | - |
? | |
| ATP + mitogen-activated protein kinase phosphatase-1 | i.e. MKP-1 | Homo sapiens | ADP + phosphorylated mitogen-activated protein kinase phosphatase-1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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