General Stability | Organism |
---|---|
N-terminal and C-terminal extensions stabilize the catalytic core | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PKI | pseudo-substrate inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | recognition motif and phosphorylation sequences, substrate binding structure, peptide binding in an extended conformation, N-terminal and C-terminal extensions bind pseudosubstrates | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme consists of an N-terminal small lobe and a C-terminal large lobe giving the catalytic core a bean-like structure and stabilizing the enzyme | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
cAMP-dependent protein kinase | - |
Homo sapiens |
PKA | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | binds between two lobes, directing the gamma-phosphate outwards while the adenine ring lies deep in the cleft between the lobes | Homo sapiens |