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Literature summary for 2.7.11.11 extracted from
- Isoforms of cAMP-dependent protein kinase in the bivalve mollusk Mytilus galloprovincialis: activation by cyclic nucleotides and effect of temperature (2004), Arch. Biochem. Biophys., 432, 71-78.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | activates isozymes PKAmyt1 and PKAmyt2 | Mytilus galloprovincialis |  |
| cGMP | activates isozymes PKAmyt1 and PKAmyt2 | Mytilus galloprovincialis | |
| additional information | isozyme PKAmyt1 shows 2- and 3.5fold higher affinity for cAMP and cGMP, respectively, than PKAmyt2 | Mytilus galloprovincialis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics, thermodynamics, isozymes PKAmyt1 and PKAmyt2 | Mytilus galloprovincialis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mytilus galloprovincialis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mytilus galloprovincialis | - |
bivalve mollusk, sea mussel, 2 isozymes PKAmyt1 and PKAmyt2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial purification of 2 isozymes PKAmyt1 and PKAmyt2 from posterior aductor muscle and mantle tissue by 2 steps of ionexchange chromatography, ammonium sulfate precipitation, and immunoaffinity chromatography | Mytilus galloprovincialis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mantle | - |
Mytilus galloprovincialis | - |
| posterior adductor muscle | - |
Mytilus galloprovincialis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mytilus galloprovincialis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Kemptide | activity of the catalytic subunit C | Mytilus galloprovincialis | ADP + Kemptide phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | isozymes PKAmyt1 and PKAmyt2 contain regulatory subunits Rmyt1 and Rmyt2, respectively | Mytilus galloprovincialis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Mytilus galloprovincialis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Mytilus galloprovincialis |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 10 | 40 | isozyme PKAmyt1 shows a linear Arrhenius plot, while PKAmyt2 shows a break in Arrhenius plot at 15°C being much more temperature-sensitive above 15°C compared to isozyme PKAmyt1 | Mytilus galloprovincialis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Mytilus galloprovincialis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mytilus galloprovincialis | |
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Release 2023.1 (January 2023)
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