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Literature summary for 2.7.11.10 extracted from

  • Ochiai, T.; Saito, Y.; Saitoh, T.; Dewan, M.Z.; Shioya, A.; Kobayashi, M.; Kawachi, H.; Muto, S.; Itai, A.; Uota, S.; Eishi, Y.; Yamamoto, N.; Tanaka, S.; Arii, S.; Yamaoka, S.
    Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells (2008), J. Med. Dent. Sci., 55, 49-59.
    View publication on PubMed
Search for more literature for 2.7.11.10

Application

Application Comment Organism
medicine inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells Mus musculus
medicine inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IMD-0354 specific IKKbeta inhibition Homo sapiens
IMD-0354 specific IKKbeta inhibition Mus musculus
RNAi specific IKKbeta inhibition Homo sapiens
RNAi specific IKKbeta inhibition Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?
ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PANC-1 cell
-
 Homo sapiens
-
pancreas
-
 Mus musculus
-
PK-8 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase beta
-
 Mus musculus
IkappaB kinase beta
-
 Homo sapiens
IKKbeta
-
 Mus musculus
IKKbeta
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function IkappaB kinase is a central kinase for nuclear factor-kappaB activation Mus musculus
physiological function IkappaB kinase is a central kinase for nuclear factor-kappaB activation Homo sapiens