Literature summary for 2.7.11.10 extracted from

Asamitsu, K.; Yamaguchi, T.; Nakata, K.; Hibi, Y.; Victoriano, A.F.; Imai, K.; Onozaki, K.; Kitade, Y.; Okamoto, T.
Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin (2008), J. Biochem., 144, 581-589.

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Application

Application	Comment	Organism
medicine	IKK is thought to be a focal target of drug development	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
Flag-IKKalpha and Flag-IKKbeta vectors for transfection of HEK293 cells are used	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
noraristeromycin	NAM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [IkappaB protein]	Homo sapiens	-	ADP + [IkappaB phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + NF-kappaB p65 subunit	IKKalpha and IKKbeta phosphorylate NF-kappaB p65 subunit at Ser536	Homo sapiens	ADP + phosphorylated NF-kappaB p65 subunit	-	?
ATP + [IkappaB protein]	-	Homo sapiens	ADP + [IkappaB phosphoprotein]	-	?

Subunits

Subunits	Comment	Organism
oligomer	IKK is a large molecular weight complex consisting of at least two catalytic subunits, IKKalpha, IKKbeta, and the associated regulatory subunit IKKgamma, NEMO	Homo sapiens

Synonyms

Synonyms	Comment	Organism
IkappaB kinase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00037	-	IKKalpha	Homo sapiens	noraristeromycin
0.00064	-	inhibited endogenous IKK activity following TNF-alpha stimulation	Homo sapiens	noraristeromycin

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Release 2023.1 (January 2023)