Literature summary for 2.7.11.10 extracted from

Sors, A.; Jean-Louis, F.; Begue, E.; Parmentier, L.; Dubertret, L.; Dreano, M.; Courtois, G.; Bachelez, H.; Michel, L.
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents (2008), Clin. Cancer Res., 14, 901-911.

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Application

Application	Comment	Organism
medicine	IKK2 inhibition represents a promising strategy for the treatment of advanced stages of cutaneous T-cell lymphomas	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a vector expressing a mutant form of IKK2 is used, characterized by the substitution of two serine residues with alanines, leading to inhibition of IKK2 autophosphorylation required for IKK activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
AS602868	-	Homo sapiens
N-(3,5-bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [IkappaB protein]	Homo sapiens	-	ADP + [IkappaB phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUT-78 cell	-	Homo sapiens	-
JURKAT cell	-	Homo sapiens	-
MyLa 2059 cell	mycosis fungoides cell line	Homo sapiens	-
SeAx cell	-	Homo sapiens	-
T-cell lymphoma cell	cutaneous T-cell lymphoma	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [IkappaB protein]	-	Homo sapiens	ADP + [IkappaB phosphoprotein]	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	IkappaB kinase, IKK, is composed of two catalytic subunits, IKK1 or IKKalpha and IKK2 or IKKbeta, and a regulatory subunit called NEMO or IKKgamma	Homo sapiens

Synonyms

Synonyms	Comment	Organism
IkappaB kinase	-	Homo sapiens
IKK	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)