Application | Comment | Organism |
---|---|---|
medicine | N-tosyl-L-phenylalanine chloromethyl ketone has been shown to have therapeutic effects in hypoxic-ischemic brain injury and collagen-induced arthritis in experimental animals, without any obvious adverse side effects | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
a Flag-tagged IKKbeta expression vector is used | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C179A | mutant, not susceptible to the inhibitor N-tosyl-L-phenylalanine chloromethyl ketone | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-tosyl-L-phenylalanine chloromethyl ketone | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
700000 | - |
IKK complex | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
cytoplasmic extracts are prepared | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | the IkappaB kinase complex is composed of two catalytic subunits, IKKalpha and IKKbeta, or IKK1 and IKK2, and a regulatory subunit, IKKgamma, NEMO or IKKAP1 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase beta | - |
Homo sapiens |
IKKbeta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | IKKbeta is shown to play an essential role in the activation of NF-kappaB in response to TNF-alpha and other inflammatory stimuli | Homo sapiens |