Application | Comment | Organism |
---|---|---|
medicine | TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | using TBK1-deficient mice it is shown by bone-marrow transfer experiments that TBK1-mediated signalling in haematopoietic cells is critical for the induction of antigen-specific B and CD41 T cells, whereas in non-haematopoietic cells TBK1 is required for CD81 T-cell induction | Mus musculus |
additional information | using TBK1-deficient mice it is shown that TBK1 mediates the adjuvant effect of DNA vaccines and is essential for its immunogenicity in mice. Plasmid-DNA-activated, TBK1-dependent signalling and the resultant type-I interferon receptor-mediated signalling is required for induction of antigen-specific B and T cells, which occurred even in the absence of innate immune signalling through a well known CpG DNA sensorToll-like receptor 9 (TLR9) or Z-DNA binding protein 1 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | A1L361 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
TANK-binding kinase 1 | - |
Mus musculus |
TBK1 | - |
Mus musculus |