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Literature summary for 2.7.11.10 extracted from

  • Ryu, M.J.; Anikin, V.; Hong, S.H.; Jeon, H.; Yu, Y.G.; Yu, M.H.; Chernysh, S.; Lee, C.
    Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha (2008), Mol. Cell. Biochem., 313, 91-102.
    View publication on PubMed
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
alloferon alloferon, a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina, activates IKK activity Homo sapiens

Application

Application Comment Organism
molecular biology NF-kappaB is activated by alloferon through down-regulation of antioxidant proteins and IkappaBalpha Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-acetylcysteine inhibits phosphorylation of IkappaBalpha Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15111
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblastoid cell line Namalva cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaBalpha
-
 Homo sapiens ADP + phosphorylated IkappaBalpha
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase alpha
-
 Homo sapiens
IKK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens