Literature summary for 2.7.11.10 extracted from

Yanai, A.; Maeda, S.; Shibata, W.; Hikiba, Y.; Sakamoto, K.; Nakagawa, H.; Ohmae, T.; Hirata, Y.; Ogura, K.; Muto, S.; Itai, A.; Omata, M.
Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils (2008), Infect. Immun., 76, 781-787.

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Application

Application	Comment	Organism
medicine	Helicobacter pylori-mediated gastric inflammation critically depends on the efficient recruitment and activation of macrophages, with sufficient NF-kappaB activation	Meriones unguiculatus

Inhibitors

Inhibitors	Comment	Organism	Structure
IMD-0354	in macrophages, the inhibition of IkappaB kinase beta (IKKbeta) results in lower proinflammatory cytokine expression caused by heat-killed Helicobacter pylori cells. Treatment with IKKbeta inhibitor results in milder inflammation in gerbils with Helicobacter pylori gastritis	Meriones unguiculatus

Organism

Organism	UniProt	Comment	Textmining
Meriones unguiculatus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	activated macrophages are significantly increased in Helicobacter pylori-infected gastric mucosa and are identified as being important cells with potent activation of NF-kappaB, which plays an important part in producing proinflammatory cytokines. Macrophage depletion by the administration of clodronate resulted in milder inflammation in gerbils infected with Helicobacter pylori	Meriones unguiculatus	-

Synonyms

Synonyms	Comment	Organism
IKKbeta	-	Meriones unguiculatus

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Release 2023.1 (January 2023)