Literature summary for 2.7.11.10 extracted from

Niederberger, E.; Geisslinger, G.
The IKK-NF-kB pathway: a source for novel molecular drug targets in pain therapy? (2008), FASEB J., 22, 3432-3442.

Search for more literature for 2.7.11.10

Protein Variants

Protein Variants	Comment	Organism
additional information	IKKbeta knock-out mice are embryonically lethal	Mus musculus
additional information	mice lacking the beta subunit of IKK in myeloid cells are more susceptible to endotoxin shock than control mice, which might be a serious challenge for long-term IKKbeta inhibition	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
BMS345541	shows efficacy in a mouse model of collagen-induced arthritis without signs of major toxicology	Mus musculus
S1627	preferentially inhibits the beta-subunit of the IKK complex. Specific inhibition of I-kappaB kinase by S1627 modulates the nociceptive response in various nociceptive models in rats. S1627 inhibits the activation of NF-kappaB in the spinal cord and thereby thermal and mechanical hyperalgesia in the zymosan-induced paw inflammation model and the inflammatory edema. It also reduces tactile and cold allodynia in a model of neuropathic pain	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88351	-	-
Rattus norvegicus	Q9QY78	-	-

Synonyms

Synonyms	Comment	Organism
IKKbeta	-	Mus musculus
IKKbeta	-	Rattus norvegicus

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Release 2023.1 (January 2023)