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Literature summary for 2.7.11.10 extracted from

  • Wilson, W.; Baldwin, A.S.
    Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer (2008), Cancer Res., 68, 8156-8163.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
glycogen synthase kinase-3beta GSK-3 is required for constitutive IKK activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of IKKalpha alone or combined IKKalpha/beta causes significant loss of NF-kappaB DNA binding activity in Panc-1 cells. The suppressive effects of IKKalpha and combined IKKalpha/beta knockdown are stronger than IKKbeta knockdown alone Homo sapiens
additional information knockdown of IKKalpha and IKKbeta by RNAi leads to a significant reduction of Panc-1 cell and MiaPaCa-2 cell growth Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
COMPOUND A leads to a significant reduction of Panc-1 cell and MiaPaCa-2 cell growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14920
-
-
Homo sapiens O15111
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MiaPaCa-2 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaBalpha
-
 Homo sapiens ADP + phosphorylated IkappaBalpha
-
 ?

Synonyms

Synonyms Comment Organism
IKKalpha
-
 Homo sapiens
IKKbeta
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens