Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TNF-alpha | - |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C179A | berberine does not have any effect on mutant IKK beta C179A. This proves that berberine inhibits IKK beta activity through the modification of Cys179 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Berberine | an isoquinoline alkaloid derived from a plant used traditionally in Chinese and Ayurvedic medicine inhibits IKK activity. Addition of DTT to the kinase reaction reverses the berberine-mediated inhibition of IKK activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14920 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
lung adenocarcinoma cell line | H1299 | Homo sapiens | - |
U-266 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IkappaBalpha | - |
Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaB alpha kinase | - |
Homo sapiens |
IKK beta | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |