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Literature summary for 2.7.11.10 extracted from

  • Pandey, M.K.; Sung, B.; Kunnumakkara, A.B.; Sethi, G.; Chaturvedi, M.M.; Aggarwal, B.B.
    Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis (2008), Cancer Res., 68, 5370-5379.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
C179A berberine does not have any effect on mutant IKK beta C179A. This proves that berberine inhibits IKK beta activity through the modification of Cys179 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Berberine an isoquinoline alkaloid derived from a plant used traditionally in Chinese and Ayurvedic medicine inhibits IKK activity. Addition of DTT to the kinase reaction reverses the berberine-mediated inhibition of IKK activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14920
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
JURKAT cell
-
Homo sapiens
-
lung adenocarcinoma cell line H1299 Homo sapiens
-
U-266 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaBalpha
-
Homo sapiens ADP + phosphorylated IkappaBalpha
-
?

Synonyms

Synonyms Comment Organism
IkappaB alpha kinase
-
Homo sapiens
IKK beta
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens