Literature summary for 2.7.11.10 extracted from

Cho, I.H.; Hong, J.; Suh, E.C.; Kim, J.H.; Lee, H.; Lee, J.E.; Lee, S.; Kim, C.H.; Kim, D.W.; Jo, E.K.; Lee, K.E.; Karin, M.; Lee, S.J.
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death (2008), Brain, 131, 3019-3033.

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Application

Application	Comment	Organism
molecular biology	IKK/nuclear factor-kappaB dependent microglia activation contributes to KA-induced hippocampal neuronal cell death in vivo through induction of inflammatory mediators	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	conditional IKKbeta knockout mice are used in which the IKKbeta gene is specifically deleted in cells of myeloid lineage, including microglia, in the CNS. This deletion reduced IkappaB kinase (IKK) activity in cultured primary microglia by up to 40% compared with wild-type. Kainic acid-induced hippocampal neuronal cell death is reduced by 30% in knockout mice compared with wild-type mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88351	-	-

Synonyms

Synonyms	Comment	Organism
IKKbeta	-	Mus musculus

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Release 2023.1 (January 2023)