Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | virus-inducible expression of IKKepsilon, IKKepsilon is activated by IFNbeta | Mus musculus |
Cloned (Comment) | Organism |
---|---|
IKKepsilon expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | disruption of Ikbke-/-, the gene encoding IKKepsilon, results in a complete loss of the kinase in both mice and embryonic fibroblasts, generation of mice lacking IKKepsilon, the mice produce normal amounts of IFNbeta, but are hypersusceptible to viral infection because of a defect in the IFN signaling pathway, phenotype, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Ikbke | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | mouse embryonic fibroblasts, MEF | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK-related kinase | - |
Mus musculus |
IKKepsilon | - |
Mus musculus |
IKKi | - |
Mus musculus |
inhibitor of nuclear factor kB kinase-related kinase | - |
Mus musculus |
TANK-binding kinase 1 | - |
Mus musculus |
TBK1 | - |
Mus musculus |